The Metro is the wisest choice being most punctual form of public transportation; but always remember it can get extremely crowded during rush hours, so watch out for your belongings as pickpockets are very adept at unzipping pockets of pants and purses on crowded trains.There are two metro lines at Termini station. Line A (red line) runs northwest past the Vatican, and south. Line B (Blue Line) runs southwest past the Colosseum and northeast.